Incubation of Negative Affect during Protracted Alcohol Withdrawal Is Age-, but Not Sex-Selective
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چکیده
منابع مشابه
Negative Affect and Excessive Alcohol Intake Incubate during Protracted Withdrawal from Binge-Drinking in Adolescent, But Not Adult, Mice
Binge-drinking is common in underage alcohol users, yet we know little regarding the biopsychological impact of binge-drinking during early periods of development. Prior work indicated that adolescent male C57BL6/J mice with a 2-week history of binge-drinking (PND28-41) are resilient to the anxiogenic effects of early alcohol withdrawal. Herein, we employed a comparable Drinking-in-the-Dark mod...
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Alcohol dependence and withdrawal has been shown to cause neuroadaptive changes at multiple levels of the nervous system. At the neuron level, adaptations of synaptic connections have been extensively studied in a number of brain areas and accumulating evidence also shows the importance of alcohol dependence-related changes in the intrinsic cellular properties of neurons. At the same time, it i...
متن کاملNegative affect is associated with alcohol, but not cigarette use in heavy drinking smokers.
Co-use of alcohol and cigarettes is highly prevalent, and heavy drinking smokers represent a large and difficult-to-treat subgroup of smokers. Negative affect, including anxiety and depressive symptomatology, has been associated with both cigarette and alcohol use independently, but less is known about the role of negative affect in heavy drinking smokers. Furthermore, while some studies have s...
متن کاملDistinct effects of protracted withdrawal on affect, craving, selective attention and executive functions among alcohol-dependent patients.
AIMS The present study examined the effects of protracted alcohol withdrawal on affectivity, craving, selective attention and executive functions (EFs) in alcohol-dependent patients. METHODS Selective attention (The D2 Cancellation Test), flexibility (Trail Making Test), inhibition (Stroop Task), decision making (Iowa Gambling Task), craving (Obsessive-Compulsive Drinking Scale) and state aff...
متن کاملSex-dependent decrease of sphingomyelinase activity during alcohol withdrawal treatment.
BACKGROUND In vitro and in vivo studies have demonstrated the role of the acid sphingomyelinase (ASM) in pathophysiological processes and alterations in response to ethanol exposure. Cellular and plasmatic ASM activities are increased in male alcohol dependent patients and decrease during physical withdrawal. METHODS Here, we analyzed the time course of ASM in male and also female acutely int...
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ژورنال
عنوان ژورنال: Brain Sciences
سال: 2020
ISSN: 2076-3425
DOI: 10.3390/brainsci10060405